Interações medicamentosas
Atazanavir + Sildenafil
Gravidade: Contraindicada
Atazanavir and Sildenafil: contraindicated interaction.
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Resumo
Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
O que esta interação significa em palavras simples
Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Sildenafil belongs to Genitourinary.
Por que acontece
Atazanavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of sildenafil, raising its plasma concentrations.
O que fazer
Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Sildenafil
- Amyl nitrite + Sildenafil Contraindicada
- Cobicistat + Sildenafil Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicada
- Glyceryl trinitrate pr + Sildenafil Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide mononitrate + Sildenafil Contraindicada
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Sildenafil?
MediHelp rates the interaction as contraindicated. Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
How serious is the interaction between Atazanavir and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Cobicistat, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.
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