Interações medicamentosas
Atorvastatin + Vitamin b3
Gravidade: Moderada
Atorvastatin and Vitamin b3: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.
O que esta interação significa em palavras simples
Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Vitamin b3 belongs to Gastrointestinal Tract.
Por que acontece
Additive myotoxicity, with a possible minor pharmacokinetic contribution; the mechanism is not fully established.
O que fazer
Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Vitamin b3
- Lovastatin + Vitamin b3 Grave
- Simvastatin + Vitamin b3 Grave
- Cholestyramine + Vitamin b3 Moderada
- Colestipol + Vitamin b3 Moderada
- Fluvastatin + Vitamin b3 Moderada
- Insulin aspart protamine / insulin aspart + Vitamin b3 Moderada
Outras interações de Atorvastatin
- Atorvastatin + Tipranavir Contraindicada
- Atazanavir + Atorvastatin Grave
- Atorvastatin + Clarithromycin Grave
- Atorvastatin + Cobicistat Grave
- Atorvastatin + Cyclosporin Grave
- Atorvastatin + Cyclosporine Grave
Perguntas frequentes
Can I take Atorvastatin with Vitamin b3?
MediHelp rates the interaction as moderate. Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.
How serious is the interaction between Atorvastatin and Vitamin b3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Cholestyramine. The full list is on the Vitamin b3 page.
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