Interações medicamentosas
Atracurium + Fentanyl intranasal
Gravidade: Grave
Atracurium and Fentanyl intranasal: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Fentanyl causes respiratory depression, sedation and hypotension, and these effects add to those of a neuromuscular blocker when ventilation is inadequate. Atracurium is given only with ventilatory support, but residual blockade plus opioid effect can delay safe recovery.
O que esta interação significa em palavras simples
Atracurium and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive respiratory depression from central opioid effect and peripheral neuromuscular blockade.
O que fazer
Use only in settings with airway and ventilatory support and monitor neuromuscular blockade, respiration and blood pressure. Reduce doses as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Atracurium
Perguntas frequentes
Can I take Atracurium with Fentanyl intranasal?
MediHelp rates the interaction as major. Atracurium and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl causes respiratory depression, sedation and hypotension, and these effects add to those of a neuromuscular blocker when ventilation is inadequate. Atracurium is given only with ventilatory support, but residual blockade plus opioid effect can delay safe recovery.
How serious is the interaction between Atracurium and Fentanyl intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in settings with airway and ventilatory support and monitor neuromuscular blockade, respiration and blood pressure. Reduce doses as needed.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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