Interações medicamentosas
Atracurium + Bacitracin-neomycin-polymyxin
Gravidade: Grave
Atracurium and Bacitracin-neomycin-polymyxin: major interaction.
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Resumo
Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
O que esta interação significa em palavras simples
Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atracurium belongs to Musculoskeletal; Bacitracin-neomycin-polymyxin belongs to Anti Bacterial.
Por que acontece
Polymyxin B and neomycin reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to non-depolarizing neuromuscular blockade.
O que fazer
Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Grave
- Bacitracin-neomycin-polymyxin + Capreomycin Grave
- Bacitracin-neomycin-polymyxin + Cidofovir Grave
- Bacitracin-neomycin-polymyxin + Cisatracurium Grave
- Bacitracin-neomycin-polymyxin + Pancuronium Grave
- Bacitracin-neomycin-polymyxin + Rocuronium Grave
Outras interações de Atracurium
Perguntas frequentes
Can I take Atracurium with Bacitracin-neomycin-polymyxin?
MediHelp rates the interaction as major. Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
How serious is the interaction between Atracurium and Bacitracin-neomycin-polymyxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Capreomycin, Cidofovir. The full list is on the Bacitracin-neomycin-polymyxin page.
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