Interações medicamentosas
Bosutinib + Imatinib
Gravidade: Grave
Bosutinib and Imatinib: major interaction.
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Resumo
Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
O que esta interação significa em palavras simples
Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Imatinib belongs to Oncology.
Por que acontece
Imatinib inhibits CYP3A4-mediated metabolism of bosutinib, reducing its clearance.
O que fazer
Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Imatinib
- Imatinib + Lomitapide Contraindicada
- Imatinib + Lonafarnib Contraindicada
- Amobarbital + Imatinib Grave
- Apalutamide + Imatinib Grave
- Avapritinib + Imatinib Grave
- Benzhydrocodone / acetaminophen + Imatinib Grave
Outras interações de Bosutinib
- Amiodarone + Bosutinib Grave
- Apalutamide + Bosutinib Grave
- Aprepitant + Bosutinib Grave
- Bosentan + Bosutinib Grave
- Bosutinib + Carbamazepine Grave
- Bosutinib + Chlorpromazine Grave
Perguntas frequentes
Can I take Bosutinib with Imatinib?
MediHelp rates the interaction as major. Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
How serious is the interaction between Bosutinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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