Interações medicamentosas
Axitinib + Clarithromycin
Gravidade: Grave
Axitinib and Clarithromycin: major interaction.
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Resumo
Strong CYP3A4 inhibitors such as clarithromycin raise axitinib exposure. This may increase hypertension, diarrhea, hemorrhage and other axitinib toxicities.
O que esta interação significa em palavras simples
Axitinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axitinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Por que acontece
Clarithromycin inhibits CYP3A4, the main metabolic pathway of axitinib.
O que fazer
Use an alternative antibiotic such as azithromycin when possible. If unavoidable, reduce the axitinib dose by about half and monitor blood pressure and tolerability.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Axitinib
- Amobarbital + Axitinib Grave
- Apalutamide + Axitinib Grave
- Atazanavir + Axitinib Grave
- Axitinib + Carbamazepine Grave
- Axitinib + Cobicistat Grave
- Axitinib + Conivaptan Grave
Perguntas frequentes
Can I take Axitinib with Clarithromycin?
MediHelp rates the interaction as major. Axitinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors such as clarithromycin raise axitinib exposure. This may increase hypertension, diarrhea, hemorrhage and other axitinib toxicities.
How serious is the interaction between Axitinib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic such as azithromycin when possible. If unavoidable, reduce the axitinib dose by about half and monitor blood pressure and tolerability.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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