Interações medicamentosas
Clarithromycin + Dihydroergotamine
Gravidade: Contraindicada
Clarithromycin and Dihydroergotamine: contraindicated interaction.
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Resumo
Clarithromycin raises dihydroergotamine concentrations and can precipitate ergotism, with severe peripheral and cerebral vasospasm and ischemia. This is a well-documented, potentially limb- or life-threatening interaction.
O que esta interação significa em palavras simples
Clarithromycin and Dihydroergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Dihydroergotamine belongs to Central Nervous System.
Por que acontece
Clarithromycin inhibits CYP3A4, reducing metabolism of dihydroergotamine.
O que fazer
Do not use together; choose a non-CYP3A4-inhibiting antibiotic such as azithromycin, and seek urgent care if numbness, coldness or ischemic symptoms appear.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine intranasal Contraindicada
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
- Dihydroergotamine + Ergotamine Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Dihydroergotamine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Dihydroergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin raises dihydroergotamine concentrations and can precipitate ergotism, with severe peripheral and cerebral vasospasm and ischemia. This is a well-documented, potentially limb- or life-threatening interaction.
How serious is the interaction between Clarithromycin and Dihydroergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-CYP3A4-inhibiting antibiotic such as azithromycin, and seek urgent care if numbness, coldness or ischemic symptoms appear.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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