Interações medicamentosas
Baclofen + Oliceridine
Gravidade: Grave
Baclofen and Oliceridine: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Opioids combined with other CNS depressants such as baclofen can produce profound sedation, respiratory depression, coma and death. Baclofen may also add to opioid-related urinary retention.
O que esta interação significa em palavras simples
Baclofen and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression from opioid agonism and GABA-B agonism.
O que fazer
Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Baclofen
Outras interações de Oliceridine
- Isocarboxazid + Oliceridine Contraindicada
- Alprazolam + Oliceridine Grave
- Amiodarone + Oliceridine Grave
- Amisulpride + Oliceridine Grave
- Amitriptyline + Oliceridine Grave
- Amobarbital + Oliceridine Grave
Perguntas frequentes
Can I take Baclofen with Oliceridine?
MediHelp rates the interaction as major. Baclofen and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants such as baclofen can produce profound sedation, respiratory depression, coma and death. Baclofen may also add to opioid-related urinary retention.
How serious is the interaction between Baclofen and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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