Interações medicamentosas
Chloramphenicol + Conivaptan
Gravidade: Grave
Chloramphenicol and Conivaptan: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Chloramphenicol can inhibit CYP3A4 and may increase conivaptan concentrations, raising the risk of overly rapid sodium correction and osmotic demyelination. Conivaptan is contraindicated with strong CYP3A inhibitors, but chloramphenicol's inhibition is less well characterized.
O que esta interação significa em palavras simples
Chloramphenicol and Conivaptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Inhibition of CYP3A4 by chloramphenicol decreases conivaptan metabolism.
O que fazer
Avoid the combination where possible; if used, monitor serum sodium frequently and watch for overcorrection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloramphenicol
Perguntas frequentes
Can I take Chloramphenicol with Conivaptan?
MediHelp rates the interaction as major. Chloramphenicol and Conivaptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4 and may increase conivaptan concentrations, raising the risk of overly rapid sodium correction and osmotic demyelination. Conivaptan is contraindicated with strong CYP3A inhibitors, but chloramphenicol's inhibition is less well characterized.
How serious is the interaction between Chloramphenicol and Conivaptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum sodium frequently and watch for overcorrection.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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