Interações medicamentosas
Bcg vaccine live + Leflunomide
Gravidade: Contraindicada
Bcg vaccine live and Leflunomide: contraindicated interaction.
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Resumo
Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
O que esta interação significa em palavras simples
Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Suppressed lymphocyte function impairs control of live attenuated organisms.
O que fazer
Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Leflunomide
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicada
- Leflunomide + Measles mumps and rubella vaccine live Contraindicada
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicada
- Leflunomide + Measles vaccine Contraindicada
- Leflunomide + Smallpox vaccine live Contraindicada
- Alefacept + Leflunomide Grave
Perguntas frequentes
Can I take Bcg vaccine live with Leflunomide?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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