Interações medicamentosas
Belladonna and opium + Butorphanol
Gravidade: Grave
Belladonna and opium and Butorphanol: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
O que esta interação significa em palavras simples
Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive opioid CNS depression combined with partial mu antagonism by butorphanol at receptors occupied by morphine from opium.
O que fazer
Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Belladonna and opium e Butorphanol, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Alfentanil + Butorphanol Grave
- Alprazolam + Butorphanol Grave
- Alvimopan + Butorphanol Grave
- Amobarbital + Butorphanol Grave
Perguntas frequentes
Can I take Belladonna and opium with Butorphanol?
MediHelp rates the interaction as major. Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
How serious is the interaction between Belladonna and opium and Butorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
