Interações medicamentosas
Benzhydrocodone / acetaminophen + Chloral hydrate
Gravidade: Grave
Benzhydrocodone / acetaminophen and Chloral hydrate: major interaction.
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Resumo
Chloral hydrate combined with an opioid can cause profound sedation, respiratory depression, coma and death. The risk rises with higher doses and longer durations.
O que esta interação significa em palavras simples
Benzhydrocodone / acetaminophen and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from sedative-hypnotic and opioid effects.
O que fazer
Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloral hydrate
Perguntas frequentes
Can I take Benzhydrocodone / acetaminophen with Chloral hydrate?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloral hydrate combined with an opioid can cause profound sedation, respiratory depression, coma and death. The risk rises with higher doses and longer durations.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chloral hydrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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