Interações medicamentosas
Brexpiprazole + Buprenorphine long-acting
Gravidade: Grave
Brexpiprazole and Buprenorphine long-acting: major interaction.
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Resumo
Brexpiprazole taken with long-acting injectable buprenorphine may produce additive sedation and respiratory depression. The prolonged release means the opioid effect cannot be quickly reversed.
O que esta interação significa em palavras simples
Brexpiprazole and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS depression from opioid partial agonism and sedating antipsychotic effects.
O que fazer
Monitor for oversedation and respiratory depression, especially when starting or increasing brexpiprazole, and counsel the patient about driving and operating machinery.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Brexpiprazole
Perguntas frequentes
Can I take Brexpiprazole with Buprenorphine long-acting?
MediHelp rates the interaction as major. Brexpiprazole and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexpiprazole taken with long-acting injectable buprenorphine may produce additive sedation and respiratory depression. The prolonged release means the opioid effect cannot be quickly reversed.
How serious is the interaction between Brexpiprazole and Buprenorphine long-acting?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression, especially when starting or increasing brexpiprazole, and counsel the patient about driving and operating machinery.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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