Interações medicamentosas
Benzhydrocodone / acetaminophen + Brexpiprazole
Gravidade: Grave
Benzhydrocodone / acetaminophen and Brexpiprazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
O que esta interação significa em palavras simples
Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive central nervous system depression from opioid agonism and the antihistaminic and antiadrenergic effects of brexpiprazole.
O que fazer
Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Brexpiprazole
Perguntas frequentes
Can I take Benzhydrocodone / acetaminophen with Brexpiprazole?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brexpiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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