Interações medicamentosas
Budesonide + Clarithromycin
Gravidade: Grave
Budesonide and Clarithromycin: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Clarithromycin strongly inhibits CYP3A4 and can markedly raise budesonide exposure, increasing the risk of systemic corticosteroid effects such as adrenal suppression and Cushingoid features. The risk is greatest with prolonged use.
O que esta interação significa em palavras simples
Budesonide and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide belongs to Respiratory; Clarithromycin belongs to Anti Bacterial.
Por que acontece
Strong CYP3A4 inhibition reduces budesonide first-pass and systemic clearance.
O que fazer
Avoid the combination with oral budesonide where possible, or use a short antibiotic course with monitoring for hypercortisolism. Consider an alternative macrolide such as azithromycin.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Referências
Outras interações de Budesonide
- Aldesleukin + Budesonide Grave
- Atazanavir + Budesonide Grave
- Bcg vaccine live + Budesonide Grave
- Budesonide + Ceritinib Grave
- Budesonide + Cobicistat Grave
- Budesonide + Darunavir Grave
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Perguntas frequentes
Can I take Budesonide with Clarithromycin?
MediHelp rates the interaction as major. Budesonide and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin strongly inhibits CYP3A4 and can markedly raise budesonide exposure, increasing the risk of systemic corticosteroid effects such as adrenal suppression and Cushingoid features. The risk is greatest with prolonged use.
How serious is the interaction between Budesonide and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination with oral budesonide where possible, or use a short antibiotic course with monitoring for hypercortisolism. Consider an alternative macrolide such as azithromycin.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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