Interações medicamentosas
Buprenorphine long-acting + Chlorpheniramine
Gravidade: Grave
Buprenorphine long-acting and Chlorpheniramine: major interaction.
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Resumo
Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
O que esta interação significa em palavras simples
Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS depression from an opioid and a sedating antihistamine.
O que fazer
Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlorpheniramine
- Belladonna and opium + Chlorpheniramine Grave
- Benzhydrocodone / acetaminophen + Chlorpheniramine Grave
- Brexanolone + Chlorpheniramine Grave
- Buprenorphine subdermal implant + Chlorpheniramine Grave
- Buprenorphine transdermal + Chlorpheniramine Grave
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine Grave
Perguntas frequentes
Can I take Buprenorphine long-acting with Chlorpheniramine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
How serious is the interaction between Buprenorphine long-acting and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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