Interações medicamentosas
Brexanolone + Chlorpheniramine
Gravidade: Grave
Brexanolone and Chlorpheniramine: major interaction.
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Resumo
Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
O que esta interação significa em palavras simples
Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS depression via GABA-A modulation and H1 antagonism.
O que fazer
Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlorpheniramine
- Belladonna and opium + Chlorpheniramine Grave
- Benzhydrocodone / acetaminophen + Chlorpheniramine Grave
- Buprenorphine long-acting + Chlorpheniramine Grave
- Buprenorphine subdermal implant + Chlorpheniramine Grave
- Buprenorphine transdermal + Chlorpheniramine Grave
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine Grave
Perguntas frequentes
Can I take Brexanolone with Chlorpheniramine?
MediHelp rates the interaction as major. Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
How serious is the interaction between Brexanolone and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
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