Interações medicamentosas
Buprenorphine long-acting + Tranylcypromine
Gravidade: Contraindicada
Buprenorphine long-acting and Tranylcypromine: contraindicated interaction.
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Resumo
Combining an MAOI with an opioid like buprenorphine can cause serotonin syndrome, and may also produce opioid toxicity with respiratory depression and coma. Because the long-acting injection cannot be quickly removed, any reaction can be prolonged.
O que esta interação significa em palavras simples
Buprenorphine long-acting and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Serotonergic excess from MAO inhibition combined with opioid effects, plus possible enhancement of opioid CNS and respiratory depression.
O que fazer
Do not use the long-acting injection in patients taking an MAOI or within 14 days of stopping one. Choose a non-serotonergic alternative or wait the washout period.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Buprenorphine long-acting with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAOI with an opioid like buprenorphine can cause serotonin syndrome, and may also produce opioid toxicity with respiratory depression and coma. Because the long-acting injection cannot be quickly removed, any reaction can be prolonged.
How serious is the interaction between Buprenorphine long-acting and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the long-acting injection in patients taking an MAOI or within 14 days of stopping one. Choose a non-serotonergic alternative or wait the washout period.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Monografias completas, posologia e verificador de interações no app MediHelp
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