Interações medicamentosas
Brimonidine + Tranylcypromine
Gravidade: Contraindicada
Brimonidine and Tranylcypromine: contraindicated interaction.
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Resumo
Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
O que esta interação significa em palavras simples
Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
O que fazer
Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Buprenorphine long-acting + Tranylcypromine Contraindicada
Outras interações de Brimonidine
- Brimonidine + Isocarboxazid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Brimonidine + Phenelzine Contraindicada
- Brimonidine + Procarbazine Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Brimonidine + Selegiline Contraindicada
Perguntas frequentes
Can I take Brimonidine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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