Interações medicamentosas
Calcium / magnesium / potassium / sodium oxybates + Clonazepam
Gravidade: Contraindicada
Calcium / magnesium / potassium / sodium oxybates and Clonazepam: contraindicated interaction.
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Resumo
Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
O que esta interação significa em palavras simples
Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
O que fazer
Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clonazepam
- Clonazepam + Sodium oxybate Contraindicada
- Alfentanil + Clonazepam Grave
- Alprazolam + Clonazepam Grave
- Amobarbital + Clonazepam Grave
- Belladonna and opium + Clonazepam Grave
- Benzhydrocodone / acetaminophen + Clonazepam Grave
Perguntas frequentes
Can I take Calcium / magnesium / potassium / sodium oxybates with Clonazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Clonazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
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