Interações medicamentosas
Clonazepam + Sodium oxybate
Gravidade: Contraindicada
Clonazepam and Sodium oxybate: contraindicated interaction.
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Resumo
Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
O que esta interação significa em palavras simples
Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clonazepam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
Por que acontece
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
O que fazer
Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clonazepam
Outras interações de Sodium oxybate
- Alprazolam + Sodium oxybate Contraindicada
- Amobarbital + Sodium oxybate Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Chloral hydrate + Sodium oxybate Contraindicada
- Clorazepate + Sodium oxybate Contraindicada
- Eszopiclone + Sodium oxybate Contraindicada
Perguntas frequentes
Can I take Clonazepam with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
How serious is the interaction between Clonazepam and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
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