Interações medicamentosas
Calcium / magnesium / potassium / sodium oxybates + Oxazepam
Gravidade: Contraindicada
Calcium / magnesium / potassium / sodium oxybates and Oxazepam: contraindicated interaction.
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Resumo
Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
O que esta interação significa em palavras simples
Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive CNS depression via GABA-B agonism by oxybate and GABA-A potentiation by oxazepam.
O que fazer
Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Oxazepam
- Oxazepam + Sodium oxybate Contraindicada
- Alfentanil + Oxazepam Grave
- Amobarbital + Oxazepam Grave
- Baclofen + Oxazepam Grave
- Belladonna and opium + Oxazepam Grave
- Benzhydrocodone / acetaminophen + Oxazepam Grave
Perguntas frequentes
Can I take Calcium / magnesium / potassium / sodium oxybates with Oxazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Oxazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Sodium oxybate, Alfentanil, Amobarbital. The full list is on the Oxazepam page.
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