Interações medicamentosas
Calcium / magnesium / potassium / sodium oxybates + Valproic acid
Gravidade: Grave
Calcium / magnesium / potassium / sodium oxybates and Valproic acid: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Valproate increases oxybate exposure, which can intensify respiratory depression, sedation and coma. Oxybates already carry serious CNS and respiratory depressant risks.
O que esta interação significa em palavras simples
Calcium / magnesium / potassium / sodium oxybates and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Valproate inhibits GHB dehydrogenase and possibly monocarboxylate transporters, reducing oxybate clearance, with additive CNS depression.
O que fazer
Reduce the nightly oxybate dose by at least 20% when valproate is started, or use a lower oxybate starting dose in patients already on valproate. Titrate by response and monitor for respiratory and CNS depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Calcium / magnesium / potassium / sodium oxybates e Valproic acid, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Valproic acid
- Ertapenem + Valproic acid Contraindicada
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicada
- Imipenem / cilastatin + Valproic acid Contraindicada
- Meropenem / vaborbactam + Valproic acid Contraindicada
- Meropenem + Valproic acid Contraindicada
- Cilastatin-imipenem + Valproic acid Grave
Perguntas frequentes
Can I take Calcium / magnesium / potassium / sodium oxybates with Valproic acid?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valproate increases oxybate exposure, which can intensify respiratory depression, sedation and coma. Oxybates already carry serious CNS and respiratory depressant risks.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the nightly oxybate dose by at least 20% when valproate is started, or use a lower oxybate starting dose in patients already on valproate. Titrate by response and monitor for respiratory and CNS depression.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
