Interações medicamentosas
Candesartan-hydrochlorothiazide + Chlorothiazide
Gravidade: Grave
Candesartan-hydrochlorothiazide and Chlorothiazide: major interaction.
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Resumo
Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
O que esta interação significa em palavras simples
Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Por que acontece
Additive diuretic and electrolyte effects of two thiazide diuretics at the distal tubule.
O que fazer
Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicada
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Acemetacin + Candesartan-hydrochlorothiazide Grave
- Amifostine + Candesartan-hydrochlorothiazide Grave
- Amiloride + Candesartan-hydrochlorothiazide Grave
Outras interações de Chlorothiazide
Perguntas frequentes
Can I take Candesartan-hydrochlorothiazide with Chlorothiazide?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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