Drug interactions
Candesartan-hydrochlorothiazide + Chlorothiazide
Severity: Major
Candesartan-hydrochlorothiazide and Chlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte effects of two thiazide diuretics at the distal tubule.
What to do
Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Chlorothiazide?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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