Interações medicamentosas
Carbamazepine + Thalidomide
Gravidade: Grave
Carbamazepine and Thalidomide: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Carbamazepine is an enzyme inducer that lowers hormonal contraceptive concentrations and can result in breakthrough ovulation. With thalidomide, contraceptive failure risks severe fetal malformations.
O que esta interação significa em palavras simples
Carbamazepine and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
Por que acontece
CYP3A4 induction by carbamazepine accelerates metabolism of contraceptive hormones.
O que fazer
Do not rely on hormonal contraceptives; use a copper IUD or other non-hormonal highly effective method with a barrier method during and after carbamazepine.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Thalidomide
- Bortezomib + Thalidomide Grave
- Griseofulvin + Thalidomide Grave
- Modafinil + Thalidomide Grave
- Nivolumab + Thalidomide Grave
- Phenytoin + Thalidomide Grave
- Rifabutin + Thalidomide Grave
Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Perguntas frequentes
Can I take Carbamazepine with Thalidomide?
MediHelp rates the interaction as major. Carbamazepine and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is an enzyme inducer that lowers hormonal contraceptive concentrations and can result in breakthrough ovulation. With thalidomide, contraceptive failure risks severe fetal malformations.
How serious is the interaction between Carbamazepine and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on hormonal contraceptives; use a copper IUD or other non-hormonal highly effective method with a barrier method during and after carbamazepine.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Griseofulvin, Modafinil. The full list is on the Thalidomide page.
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