Interações medicamentosas
Carbenoxolone + Furosemide
Gravidade: Grave
Carbenoxolone and Furosemide: major interaction.
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Resumo
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to furosemide-induced hypokalemia. It may also oppose diuretic and antihypertensive effects.
O que esta interação significa em palavras simples
Carbenoxolone and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Inhibition of 11-beta-hydroxysteroid dehydrogenase causes mineralocorticoid excess, additive with loop diuretic kaliuresis.
O que fazer
Monitor serum potassium and blood pressure closely and supplement potassium, or avoid the combination in patients with heart disease or on digoxin.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Furosemide
- Amifostine + Furosemide Grave
- Amikacin + Furosemide Grave
- Cephaloridine + Furosemide Grave
- Cisplatin + Furosemide Grave
- Digoxin + Furosemide Grave
- Ethacrynic acid + Furosemide Grave
Perguntas frequentes
Can I take Carbenoxolone with Furosemide?
MediHelp rates the interaction as major. Carbenoxolone and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to furosemide-induced hypokalemia. It may also oppose diuretic and antihypertensive effects.
How serious is the interaction between Carbenoxolone and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure closely and supplement potassium, or avoid the combination in patients with heart disease or on digoxin.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Cephaloridine. The full list is on the Furosemide page.
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