Interações medicamentosas
Cephaloridine + Furosemide
Gravidade: Grave
Cephaloridine and Furosemide: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
O que esta interação significa em palavras simples
Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive proximal tubular toxicity, with diuretic-induced volume depletion increasing renal cephaloridine accumulation.
O que fazer
Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Furosemide
- Amifostine + Furosemide Grave
- Amikacin + Furosemide Grave
- Carbenoxolone + Furosemide Grave
- Cisplatin + Furosemide Grave
- Digoxin + Furosemide Grave
- Ethacrynic acid + Furosemide Grave
Perguntas frequentes
Can I take Cephaloridine with Furosemide?
MediHelp rates the interaction as major. Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
How serious is the interaction between Cephaloridine and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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