Interações medicamentosas
Carbidopa-entacapone-levodopa + Sapropterin
Gravidade: Moderada
Carbidopa-entacapone-levodopa and Sapropterin: moderate interaction.
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Resumo
Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
O que esta interação significa em palavras simples
Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
Por que acontece
Not firmly established; possibly enhanced dopaminergic and nitric oxide pathway activity.
O que fazer
Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicada
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicada
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicada
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicada
- Amisulpride + Carbidopa-entacapone-levodopa Grave
- Asenapine transdermal + Carbidopa-entacapone-levodopa Grave
Outras interações de Sapropterin
- Avanafil + Sapropterin Moderada
- Carbidopa-levodopa + Sapropterin Moderada
- Levodopa + Sapropterin Moderada
- Methotrexate + Sapropterin Moderada
- Phenobarbitone + Sapropterin Moderada
- Pyrimethamine + Sapropterin Moderada
Perguntas frequentes
Can I take Carbidopa-entacapone-levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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