Interações medicamentosas
Carbidopa-entacapone-levodopa + Phenelzine
Gravidade: Contraindicada
Carbidopa-entacapone-levodopa and Phenelzine: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
O que esta interação significa em palavras simples
Carbidopa-entacapone-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
O que fazer
Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Carbidopa-entacapone-levodopa e Phenelzine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicada
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicada
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicada
- Amisulpride + Carbidopa-entacapone-levodopa Grave
- Asenapine transdermal + Carbidopa-entacapone-levodopa Grave
- Carbidopa-entacapone-levodopa + Chlorpromazine Grave
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Carbidopa-entacapone-levodopa with Phenelzine?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-entacapone-levodopa page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
