Interações medicamentosas
Carbimazole + Rosuvastatin
Gravidade: Moderada
Carbimazole and Rosuvastatin: moderate interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
O que esta interação significa em palavras simples
Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbimazole belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Por que acontece
Pharmacodynamic and indirect: drug-induced hypothyroidism predisposes to statin myotoxicity. No direct CYP or transporter interaction is expected.
O que fazer
Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Referências
- Crestor (rosuvastatin calcium) Prescribing Information - Warnings and Precautions: Myopathy and Rhabdomyolysis — FDA Label
- Neo-Mercazole (carbimazole) Summary of Product Characteristics — EMA SmPC
Outras interações de Carbimazole
- Carbimazole + Tiratricol Moderada
Outras interações de Rosuvastatin
Perguntas frequentes
Can I take Carbimazole with Rosuvastatin?
MediHelp rates the interaction as moderate. Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
How serious is the interaction between Carbimazole and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
What other medicines interact with Carbimazole?
MediHelp also lists interactions of Carbimazole with, for example, Tiratricol. The full list is on the Carbimazole page.
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