Interações medicamentosas
Cefaclor + Kanamycin
Gravidade: Moderada
Cefaclor and Kanamycin: moderate interaction.
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Resumo
Kanamycin is nephrotoxic and ototoxic, and cephalosporins have been reported occasionally to add to renal injury when given with aminoglycosides. Cefaclor is among the cephalosporins with a lower nephrotoxic potential, so the added risk is modest but relevant in patients with existing renal impairment.
O que esta interação significa em palavras simples
Cefaclor and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxicity, with possible reduction of aminoglycoside clearance when renal function worsens.
O que fazer
Monitor serum creatinine and urine output during combined therapy, and monitor aminoglycoside levels and hearing where applicable. Adjust doses to renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefaclor
- Bcg vaccine live + Cefaclor Moderada
- Cefaclor + Cholera vaccine Moderada
- Cefaclor + Microbiota Moderada
- Cefaclor + Plazomicin Moderada
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Cefaclor + Typhoid vaccine live Moderada
Perguntas frequentes
Can I take Cefaclor with Kanamycin?
MediHelp rates the interaction as moderate. Cefaclor and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kanamycin is nephrotoxic and ototoxic, and cephalosporins have been reported occasionally to add to renal injury when given with aminoglycosides. Cefaclor is among the cephalosporins with a lower nephrotoxic potential, so the added risk is modest but relevant in patients with existing renal impairment.
How serious is the interaction between Cefaclor and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy, and monitor aminoglycoside levels and hearing where applicable. Adjust doses to renal function.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Microbiota. The full list is on the Cefaclor page.
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