Interações medicamentosas
Cephaloridine + Tobramycin
Gravidade: Grave
Cephaloridine and Tobramycin: major interaction.
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Resumo
Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
O que esta interação significa em palavras simples
Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive proximal tubular toxicity, with reduced renal clearance of tobramycin raising its exposure.
O que fazer
Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tobramycin
- Cidofovir + Tobramycin Contraindicada
- Adefovir + Tobramycin Grave
- Amikacin + Tobramycin Grave
- Amphotericin b deoxycholate + Tobramycin Grave
- Amphotericin b + Tobramycin Grave
- Atracurium + Tobramycin Grave
Perguntas frequentes
Can I take Cephaloridine with Tobramycin?
MediHelp rates the interaction as major. Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
How serious is the interaction between Cephaloridine and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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