Interações medicamentosas
Ceritinib + Vincristine
Gravidade: Grave
Ceritinib and Vincristine: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
O que esta interação significa em palavras simples
Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Vincristine belongs to Oncology.
Por que acontece
Ceritinib inhibits CYP3A4-mediated metabolism of vincristine, raising its plasma concentrations.
O que fazer
Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicada
- Apalutamide + Vincristine Grave
- Atazanavir + Vincristine Grave
- Chloramphenicol + Vincristine Grave
- Clarithromycin + Vincristine Grave
- Cobicistat + Vincristine Grave
Outras interações de Ceritinib
- Ceritinib + Cisapride Contraindicada
- Ceritinib + Eletriptan Contraindicada
- Ceritinib + Flibanserin Contraindicada
- Ceritinib + Pimozide Contraindicada
- Ceritinib + Thioridazine Contraindicada
- Ceritinib + Tolvaptan Contraindicada
Perguntas frequentes
Can I take Ceritinib with Vincristine?
MediHelp rates the interaction as major. Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
How serious is the interaction between Ceritinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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