Interações medicamentosas
Clarithromycin + Vincristine
Gravidade: Grave
Clarithromycin and Vincristine: major interaction.
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Resumo
Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
O que esta interação significa em palavras simples
Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Vincristine belongs to Oncology.
Por que acontece
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of vincristine by clarithromycin.
O que fazer
Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicada
- Apalutamide + Vincristine Grave
- Atazanavir + Vincristine Grave
- Ceritinib + Vincristine Grave
- Chloramphenicol + Vincristine Grave
- Cobicistat + Vincristine Grave
Perguntas frequentes
Can I take Clarithromycin with Vincristine?
MediHelp rates the interaction as major. Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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