Interações medicamentosas
Chlorpromazine + Givinostat
Gravidade: Grave
Chlorpromazine and Givinostat: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.
O que esta interação significa em palavras simples
Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Por que acontece
Additive QT prolongation through effects on cardiac repolarization.
O que fazer
Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicada
- Chlorpromazine + Dronedarone Contraindicada
- Chlorpromazine + Droperidol Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Chlorpromazine + Metrizamide Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
Outras interações de Givinostat
- Abiraterone + Givinostat Grave
- Amiodarone + Givinostat Grave
- Amisulpride + Givinostat Grave
- Amitriptyline + Givinostat Grave
- Anagrelide + Givinostat Grave
- Asenapine + Givinostat Grave
Perguntas frequentes
Can I take Chlorpromazine with Givinostat?
MediHelp rates the interaction as major. Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.
How serious is the interaction between Chlorpromazine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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