Interações medicamentosas
Anagrelide + Givinostat
Gravidade: Grave
Anagrelide and Givinostat: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Givinostat can prolong the QTc interval, and anagrelide has a similar effect, so together they may increase the risk of ventricular arrhythmia. The risk is higher with electrolyte abnormalities or existing cardiac conditions.
O que esta interação significa em palavras simples
Anagrelide and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Givinostat belongs to Miscellaneous.
Por que acontece
Additive pharmacodynamic prolongation of the QT interval.
O que fazer
Avoid the combination if possible. If used together, obtain ECGs at initiation and during treatment, and withhold givinostat if QTc exceeds 500 ms or rises substantially from baseline.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Anagrelide e Givinostat, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Referências
Outras interações de Anagrelide
- Anagrelide + Panobinostat Contraindicada
- Anagrelide + Pimozide Contraindicada
- Anagrelide + Thioridazine Contraindicada
- Anagrelide + Vandetanib Contraindicada
- Abrocitinib + Anagrelide Grave
- Alfuzosin + Anagrelide Grave
Outras interações de Givinostat
Perguntas frequentes
Can I take Anagrelide with Givinostat?
MediHelp rates the interaction as major. Anagrelide and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QTc interval, and anagrelide has a similar effect, so together they may increase the risk of ventricular arrhythmia. The risk is higher with electrolyte abnormalities or existing cardiac conditions.
How serious is the interaction between Anagrelide and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used together, obtain ECGs at initiation and during treatment, and withhold givinostat if QTc exceeds 500 ms or rises substantially from baseline.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
