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Interações medicamentosas

Chlorpromazine + Macimorelin

Gravidade: Grave

Chlorpromazine and Macimorelin: major interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.

O que esta interação significa em palavras simples

Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chlorpromazine belongs to Central Nervous System; Macimorelin belongs to Endocrine.

Nível de evidência: Moderate

Por que acontece

Additive QT prolongation through effects on cardiac repolarization.

O que fazer

Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Chlorpromazine with Macimorelin?

MediHelp rates the interaction as major. Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.

How serious is the interaction between Chlorpromazine and Macimorelin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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