Drug interactions
Chlorpromazine + Macimorelin
Severity: Major
Chlorpromazine and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.
What this interaction means in plain words
Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Chlorpromazine with Macimorelin?
MediHelp rates the interaction as major. Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.
How serious is the interaction between Chlorpromazine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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