Interações medicamentosas
Chlorpromazine + Vandetanib
Gravidade: Contraindicada
Chlorpromazine and Vandetanib: contraindicated interaction.
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Resumo
Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.
O que esta interação significa em palavras simples
Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Por que acontece
Additive blockade of cardiac potassium channels leading to QT prolongation.
O que fazer
Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicada
- Chlorpromazine + Dronedarone Contraindicada
- Chlorpromazine + Droperidol Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Chlorpromazine + Metrizamide Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
Outras interações de Vandetanib
- Amiodarone + Vandetanib Contraindicada
- Amisulpride + Vandetanib Contraindicada
- Amitriptyline + Vandetanib Contraindicada
- Anagrelide + Vandetanib Contraindicada
- Asenapine + Vandetanib Contraindicada
- Chloroquine + Vandetanib Contraindicada
Perguntas frequentes
Can I take Chlorpromazine with Vandetanib?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.
How serious is the interaction between Chlorpromazine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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