Interações medicamentosas
Glipizide + Insulin glargine-lixisenatide
Gravidade: Grave
Glipizide and Insulin glargine-lixisenatide: major interaction.
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Resumo
Glipizide stimulates insulin secretion, so combining it with insulin and lixisenatide raises the risk of hypoglycemia, which can be severe. The risk is higher in older patients and those with renal or hepatic impairment or irregular meals.
O que esta interação significa em palavras simples
Glipizide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Por que acontece
Additive glucose lowering from sulfonylurea-driven insulin secretion plus exogenous insulin and GLP-1 receptor agonism.
O que fazer
Consider reducing the glipizide dose when starting this product and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Grave
- Chlorpropamide + Insulin glargine-lixisenatide Grave
- Dulaglutide + Insulin glargine-lixisenatide Grave
- Ethanol + Insulin glargine-lixisenatide Grave
- Exenatide injectable + Insulin glargine-lixisenatide Grave
- Glimepiride + Insulin glargine-lixisenatide Grave
Outras interações de Glipizide
- Disopyramide + Glipizide Grave
- Fluconazole + Glipizide Grave
- Glipizide + Insulin degludec-liraglutide Grave
- Glipizide + Sulfamethoxazole Grave
- Aceclofenac + Glipizide Moderada
- Acemetacin + Glipizide Moderada
Perguntas frequentes
Can I take Glipizide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Glipizide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glipizide stimulates insulin secretion, so combining it with insulin and lixisenatide raises the risk of hypoglycemia, which can be severe. The risk is higher in older patients and those with renal or hepatic impairment or irregular meals.
How serious is the interaction between Glipizide and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when starting this product and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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