Interações medicamentosas
Ciprofloxacin + Dexamethasone-tobramycin
Gravidade: Grave
Ciprofloxacin and Dexamethasone-tobramycin: major interaction.
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Resumo
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinopathy and tendon rupture, especially in older patients. Risk is greatest with systemic corticosteroid exposure.
O que esta interação significa em palavras simples
Ciprofloxacin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Por que acontece
Additive tendon toxicity through impaired collagen turnover and tenocyte damage.
O que fazer
Avoid the combination in older patients or transplant recipients where possible. Stop ciprofloxacin and rest the limb if tendon pain or swelling appears.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexamethasone-tobramycin
Outras interações de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Ciprofloxacin + Thioridazine Contraindicada
- Ciprofloxacin + Tizanidine Contraindicada
- Ciprofloxacin + Vandetanib Contraindicada
- Alosetron + Ciprofloxacin Grave
Perguntas frequentes
Can I take Ciprofloxacin with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Ciprofloxacin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinopathy and tendon rupture, especially in older patients. Risk is greatest with systemic corticosteroid exposure.
How serious is the interaction between Ciprofloxacin and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients or transplant recipients where possible. Stop ciprofloxacin and rest the limb if tendon pain or swelling appears.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Cisplatin. The full list is on the Dexamethasone-tobramycin page.
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