Interações medicamentosas
Colistin + Dexamethasone-tobramycin
Gravidade: Grave
Colistin and Dexamethasone-tobramycin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Colistin and tobramycin are both nephrotoxic and may cause neurotoxicity, so combined systemic use increases the risk of acute kidney injury. Neuromuscular blockade is also additive.
O que esta interação significa em palavras simples
Colistin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Por que acontece
Additive tubular toxicity and neuromuscular blocking effects.
O que fazer
Avoid the combination unless needed for resistant infection. If used, monitor serum creatinine daily, tobramycin levels and neurological or respiratory status.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Colistin e Dexamethasone-tobramycin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Dexamethasone-tobramycin
Outras interações de Colistin
- Colistin + Polymyxin b Contraindicada
- Amikacin + Colistin Grave
- Amphotericin b deoxycholate + Colistin Grave
- Amphotericin b + Colistin Grave
- Atracurium + Colistin Grave
- Bacitracin + Colistin Grave
Perguntas frequentes
Can I take Colistin with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Colistin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin and tobramycin are both nephrotoxic and may cause neurotoxicity, so combined systemic use increases the risk of acute kidney injury. Neuromuscular blockade is also additive.
How serious is the interaction between Colistin and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless needed for resistant infection. If used, monitor serum creatinine daily, tobramycin levels and neurological or respiratory status.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
