Interações medicamentosas
Ciprofloxacin + Glibenclamide
Gravidade: Grave
Ciprofloxacin and Glibenclamide: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
O que esta interação significa em palavras simples
Ciprofloxacin and Glibenclamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Glibenclamide belongs to Endocrine.
Por que acontece
Fluoroquinolone effects on beta-cell insulin release add to sulfonylurea stimulation of insulin secretion, and ciprofloxacin may also reduce glyburide clearance.
O que fazer
Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Ciprofloxacin e Glibenclamide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Referências
Outras interações de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Ciprofloxacin + Thioridazine Contraindicada
- Ciprofloxacin + Tizanidine Contraindicada
- Ciprofloxacin + Vandetanib Contraindicada
- Alosetron + Ciprofloxacin Grave
Outras interações de Glibenclamide
- Bosentan + Glibenclamide Contraindicada
- Cholic acid + Glibenclamide Grave
- Clarithromycin + Glibenclamide Grave
- Fluconazole + Glibenclamide Grave
- Glibenclamide + Insulin degludec-liraglutide Grave
- Glibenclamide + Miconazole Grave
Perguntas frequentes
Can I take Ciprofloxacin with Glibenclamide?
MediHelp rates the interaction as major. Ciprofloxacin and Glibenclamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
How serious is the interaction between Ciprofloxacin and Glibenclamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
