Interações medicamentosas
Bosentan + Glibenclamide
Gravidade: Contraindicada
Bosentan and Glibenclamide: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
O que esta interação significa em palavras simples
Bosentan and Glibenclamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Por que acontece
Bosentan CYP2C9/3A4 induction reduces glibenclamide levels; additive hepatocellular toxicity
O que fazer
Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Glibenclamide
Outras interações de Bosentan
- Bosentan + Cyclosporin Contraindicada
- Bosentan + Glyburide-metformin Contraindicada
- Bosentan + Lonafarnib Contraindicada
- Bosentan + Sparsentan Contraindicada
- Artemether / lumefantrine + Bosentan Grave
- Atazanavir + Bosentan Grave
Perguntas frequentes
Can I take Bosentan with Glibenclamide?
MediHelp rates the interaction as contraindicated. Bosentan and Glibenclamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
How serious is the interaction between Bosentan and Glibenclamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Cholic acid, Ciprofloxacin, Clarithromycin. The full list is on the Glibenclamide page.
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