Interações medicamentosas
Citric acid / glucono-delta-lactone / magnesium carbonate + Misoprostol
Gravidade: Moderada
Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol: moderate interaction.
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Resumo
Magnesium-containing preparations can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacid use may also modestly lower systemic exposure to misoprostol acid.
O que esta interação significa em palavras simples
Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive osmotic laxative effect of magnesium with misoprostol-induced intestinal secretion and motility, plus possible reduced absorption of the active acid.
O que fazer
Prefer an aluminum- or calcium-based antacid without magnesium if one is required. Monitor for diarrhea and dehydration.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Misoprostol
Perguntas frequentes
Can I take Citric acid / glucono-delta-lactone / magnesium carbonate with Misoprostol?
MediHelp rates the interaction as moderate. Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing preparations can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacid use may also modestly lower systemic exposure to misoprostol acid.
How serious is the interaction between Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an aluminum- or calcium-based antacid without magnesium if one is required. Monitor for diarrhea and dehydration.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Oxytocin, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Misoprostol page.
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