Referência de medicamentos
Misoprostol
Misoprostol is a medicine in the class gastrointestinal tract. It is used for peptic ulcer.
- Classe do medicamento: Gastrointestinal Tract
- Indicado para: peptic ulcer
Última atualização
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Pontos-chave
- Classe do medicamento
- Gastrointestinal Tract
- Formas farmacêuticas comuns
- comprimido, solução
- Concentrações comuns
- 200 mcg, 10 g/100 ml, 25 mcg
- Interações conhecidas
- 5 (Grave: 1 · Moderada: 4)
- Nomes comerciais
- 8
- Países e mercados
- 3
Para que é usado
Como funciona
Synthetic prostaglandin E analogue parent drug that is rapidly deesterified to misoprostol acid (active metabolite) and replaces protective prostaglandins consumed with therapies that inhibit prostaglandin synthesis; inhibits gastric acid secretion and protects gastric mucosa.
Dose habitual em adultos (resumo da bula)
NSAID-Induced Ulcer (Prophylaxis): 200 mcg PO q6hr with food; may be decreased to 100 mcg q6hr if higher dose is not tolerated; last dose to be administered at bedtime
Gravidez e amamentação
- Gravidez
- Unsafe Contraindicated in pregnancy except licensed obstetric uses: it can cause miscarriage, uterine rupture and bleeding, and 1st-trimester exposure is linked to skull, facial, cranial nerve and limb defects. Women who could become pregnant need reliable contraception.
- Amamentação
- Safe Converted to an active acid that reaches milk only in very low amounts, and prostaglandins occur naturally in milk. LactMed: amounts are trivial, no special precautions; postpartum use is fine. US label: use with caution.
Efeitos adversos relatados
- Headache
- Diarrhea
- Abdominal pain
Contraindicações
- Pregnancy when used to reduce risk of NSAID-induced ulcers
- Hypersensitivity to misoprostol, prostaglandins, or prostaglandin analogues
Quem deve ter cuidado
- Misoprostol may cause birth defects, abortion (sometimes incomplete), premature labor or rupture of the uterus if given to pregnant women.
- Misoprostol should be taken only according to the directions given by a physician.
- For hospital use only if misoprostol were to be used for cervical ripening, induction of labor, or for the treatment of serious post-partum hemorrhage.
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Principais interações (5)
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Perguntas frequentes
What is Misoprostol used for?
Misoprostol is a medicine in the class gastrointestinal tract. It is used for Peptic ulcer, Pregnancy termination.
What side effects have been reported with Misoprostol?
Headache, Diarrhea, Abdominal pain.
Can Misoprostol be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy except licensed obstetric uses: it can cause miscarriage, uterine rupture and bleeding, and 1st-trimester exposure is linked to skull, facial, cranial nerve and limb defects. Women who could become pregnant need reliable contraception. Breastfeeding: Safe. Converted to an active acid that reaches milk only in very low amounts, and prostaglandins occur naturally in milk. LactMed: amounts are trivial, no special precautions; postpartum use is fine. US label: use with caution.
What does Misoprostol interact with?
MediHelp lists 5 known interactions for Misoprostol. Major: 1 · Moderate: 4. The most serious include Oxytocin, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate.
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