Interações medicamentosas
Clarithromycin + Duvelisib
Gravidade: Grave
Clarithromycin and Duvelisib: major interaction.
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Resumo
Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.
O que esta interação significa em palavras simples
Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Duvelisib belongs to Oncology.
Por que acontece
Clarithromycin is a strong CYP3A4 inhibitor that reduces duvelisib metabolism; duvelisib is itself a CYP3A4 inhibitor.
O que fazer
Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Duvelisib
- Duvelisib + Ergotamine Contraindicada
- Alfuzosin + Duvelisib Grave
- Apalutamide + Duvelisib Grave
- Avanafil + Duvelisib Grave
- Carbamazepine + Duvelisib Grave
- Chloramphenicol + Duvelisib Grave
Perguntas frequentes
Can I take Clarithromycin with Duvelisib?
MediHelp rates the interaction as major. Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.
How serious is the interaction between Clarithromycin and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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