Interações medicamentosas
Clarithromycin + Glyburide-metformin
Gravidade: Grave
Clarithromycin and Glyburide-metformin: major interaction.
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Resumo
Clarithromycin has been associated with severe hypoglycemia in patients taking sulfonylureas such as glyburide. Cases have required emergency treatment, particularly in older adults and those with renal impairment.
O que esta interação significa em palavras simples
Clarithromycin and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Glyburide-metformin belongs to Endocrine.
Por que acontece
Clarithromycin may raise glyburide exposure through CYP3A4 and P-glycoprotein inhibition and may also stimulate insulin release.
O que fazer
Where possible choose a non-macrolide antibiotic such as doxycycline or a different agent. If co-prescribed, monitor blood glucose closely and consider reducing the glyburide dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Glyburide-metformin
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Glyburide-metformin?
MediHelp rates the interaction as major. Clarithromycin and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin has been associated with severe hypoglycemia in patients taking sulfonylureas such as glyburide. Cases have required emergency treatment, particularly in older adults and those with renal impairment.
How serious is the interaction between Clarithromycin and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-macrolide antibiotic such as doxycycline or a different agent. If co-prescribed, monitor blood glucose closely and consider reducing the glyburide dose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Contrast media. The full list is on the Glyburide-metformin page.
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