Interações medicamentosas
Clarithromycin + Umeclidinium-vilanterol
Gravidade: Grave
Clarithromycin and Umeclidinium-vilanterol: major interaction.
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Resumo
Clarithromycin prolongs the QT interval and also inhibits CYP3A4 and P-glycoprotein, which can increase systemic vilanterol exposure. Both effects may raise the risk of tachycardia and ventricular arrhythmia.
O que esta interação significa em palavras simples
Clarithromycin and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Por que acontece
CYP3A4 inhibition raising vilanterol exposure, plus additive QT prolongation.
O que fazer
Prefer an alternative antibiotic such as azithromycin with caution or a non-macrolide agent. If unavoidable, monitor ECG, electrolytes and heart rate for cardiovascular beta-agonist effects.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Umeclidinium-vilanterol
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Clarithromycin and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin prolongs the QT interval and also inhibits CYP3A4 and P-glycoprotein, which can increase systemic vilanterol exposure. Both effects may raise the risk of tachycardia and ventricular arrhythmia.
How serious is the interaction between Clarithromycin and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic such as azithromycin with caution or a non-macrolide agent. If unavoidable, monitor ECG, electrolytes and heart rate for cardiovascular beta-agonist effects.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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